Genome-wide association studies of LRRK2 modifiers of Parkinson's disease
Dongbing Lai, Babak Alipanahi, Pierre Fontanillas, Tae-Hwi Linus Schwantes-An, Jan Olav Aasly, Roy N. Alcalay, Gary W. Beecham, Daniela Berg, Susan Bressman, Alexis Brice, Kathrin Brockmann, Lorraine N. Clark, Mark Cookson, Sayantan Das, Vivianna M. Van Deerlin, , Tatiana Foroud
This study identifies genetic modifiers of LRRK2 mutations in Parkinson's disease, finding a significant variant in CORO1C and a polygenic risk score effect on penetrance.
Annals of Neurology · May 3, 2021Peer-reviewedGenetic & Genomic Medicine