Polygenic hazard score is associated with prostate cancer in multi-ethnic populations
Minh‐Phuong Huynh‐Le, Chun Chieh Fan, Roshan A. Karunamuni, Wesley Kurt Thompson, Marı́a Elena Martı́nez, Rosalind A. Eeles, Zsofia Kote‐Jarai, Kenneth Ross Muir, UKGPCS collaborators, Johanna Schleutker, Nora Pashayan, Jyotsna Batra, APCB (Australian Prostate Cancer BioResource), Henrik Grönberg, David E Neal, , Tyler M. Seibert
This study evaluates a polygenic hazard score in multi-ethnic populations and finds it is associated with age at prostate cancer diagnosis, aggressive diagnosis, and death across European, Asian, and African ancestries.
Nature Communications · Feb 23, 2021Peer-reviewedGenetic & Genomic Medicine