Rare protein-coding variation and the genetic architecture of height in >1.4 million individuals
Jack A. Kosmicki, Liron Ganel, Kyoko Watanabe, Tyler Joseph, Sheila M. Gaynor, Michael D. Kessler, Joshua Backman, Joelle S. Mbatchou, Andrey Ziyatdinov, David Blair, Jonas Bovijn, Niek Verweij, Kathie Sun, Chuanyi Zhang, Suganthi Balasubramanian, , Adam E. Locke
This study identifies 207 height-associated genes using rare protein-altering variants from over 1.4 million individuals, showing large effect sizes and overlap with Mendelian height syndromes.
medRxiv · Jun 24, 2026 · PreprintGenetic & Genomic Medicine