Genomic analysis of Klebsiella pneumoniae causing community-acquired respiratory deaths among Zambian infants and children using targeted RNA-probe hybridization-capture metagenomics
Kenneth Lindstedt, Alyse Wheelock, Mulemba Samutela, Wasifa Kabir, Mwelwa Chasaya, Natasha Namuziya, Emilia Jumbe Marsden, Monica Kapasa, Chibamba N. Mumba, Bwalya Mulenga, Kafula Lisa Nkole, Rachel C Pieciak, Victor C. Mudenda, Chilufya Chikoti, Benard Ngoma, , Christopher John Gill
This study uses metagenomic sequencing to analyze Klebsiella pneumoniae from lung biopsies of Zambian children, identifying genetic sublineages, antimicrobial resistance, and potential vaccine targets.
bioRxiv · Apr 15, 2026 · PreprintMicrobiology