The SEA-AD DREAM Challenge: Community benchmarking human and AI agent solutions for Alzheimer's disease neuropathology prediction from single-nucleus transcriptomics
Hsin-Yu Lai, Nikolaos Kalavros, Verena Chung, Eitan S Kaplan, Julio Sáez-Rodríguez, Lingyi Cai, Dimitris Anastassiou, Erica Chen, Ignacio Garach Vélez, Gamze Gürsoy, Luis Javier Herrera, Xiaoting Li, Eric R. Londin, Phillipe Loher, Iliza Nazeraj, , Mariano I. Gabitto
The paper presents a benchmarking challenge to predict Alzheimer's disease neuropathology from single-nucleus transcriptomics using human and AI models, finding that top methods achieve near-perfect categorical staging predictions.
bioRxiv · Aug 11, 2026 · PreprintNeuroscience