Plague-driven selection enriched familial Mediterranean fever mutations in Armenia
Anahit M. Hovhannisyan, Mariya Antonosyan, Arsen A. Bobokhyan, Հասմիկ Սիմոնյան, Levon Aghikyan, Pavel S. Avetisyan, Mikayel Badalyan, Hakob Simonyan, Meri Safaryan, Artak V. Gnuni, Пилипосян Ашот Суренович, Avetis Grigoryan, MELINE SIMONYAN, Artavazd Zaqyan, Mkrtich H. Zardaryan, , Andrea Manica
The paper identifies recent positive selection of MEFV mutations in Armenians linked to the first Yersinia pestis plague pandemic, suggesting resistance to plague as the selective agent.
bioRxiv · Sep 16, 2026 · PreprintGenomics