Inferring binding specificities of human transcription factors with the wisdom of crowds
Nikita Gryzunov, Dmitry Penzar, Vasilii Kamenets, Valery Vyaltsev, Ivan Kozin, Irina A. Eliseeva, Vladimir Nozdrin, Ilya E. Vorontsov, Sergey Bushuev, Vadim V. Strekalovskikh, Arsenii O. Zinkevich, Gregory Andrews, Matwej Bedarew, Ido Blass, Dmitry Frolov, , Ivan V. Kulakovskiy
The paper benchmarks methods for inferring transcription factor binding specificities using a large community challenge and finds deep learning models outperform traditional methods, though positional weight matrices are competitive.
Cell Reports · Oct 1, 2026Peer-reviewedBioinformatics