Genetic & Genomic MedicinemedRxivPreprint
Trisomy 21 Drives ADARB1 Overexpression and Premature RNA Recoding in the Developing Fetal Brain
Michael S. Breen, Andy Yang, Xuran Wang…·Joseph D. Buxbaum
This study identifies ADARB1 overexpression in T21 fetal brain due to trisomy 21, leading to increased A-to-I RNA editing and altered GRIA gene recoding.
DOI 10.1101/2025.11.13.25339504