BioinformaticsbioRxivPreprint
Antibody optimization enabled by artificial intelligence predictions of binding affinity and naturalness
Sharrol T. Bachas, Goran Rakocevic, David Spencer…·Roberto Spreafico
Language models trained on high-throughput affinity data predict KD of unseen antibody variants across three orders of magnitude, and a "naturalness" score can be optimised alongside affinity.
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