Proceedings of the National Academy of SciencesGeneticsPeer-reviewed journal article
Commentary on "Limitations of GCTA as a solution to the missing heritability problem"
Jian YangiD, Sang Hong Lee, Naomi R. WrayiD, Michael E. Goddard, Peter M Visscher
Abstract
In a recent publication entitled \"Limitations of GCTA as a solution to the missing heritability problem\" Krishna Kumar et al. (2015 PNAS) claim that \"GCTA applied to current SNP data cannot produce reliable or stable estimates of heritability\". Here we show that those claims are false and that results presented by Krishna Kumar et al. are in fact entirely consistent with and can be predicted from the theory underlying GCTA.
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