Neural System Identification with Neural Information Flow

Cortical information flow (CIF) is a new framework for system identification in neuroscience. CIF models represent neural systems as coupled brain regions that each embody neural computations. These brain regions are coupled to observed data specific to that region. Neural computations are estimated via stochastic gradient descent. We show using a large-scale fMRI dataset that, in this manner, we can estimate models that learn meaningful neural computations. Our framework is general in the sense that it can be used in conjunction with any (combination of) neural recording techniques. It is also scalable, providing neuroscientists with a principled approach to make sense of the high-dimensional neural datasets.