Inter-individual differences in human brain structure and morphometry link to population variation in demographics and behavior

Abstract

We perform a comprehensive integrative analysis of multiple structural MR-based brain features and find strong evidence relating inter-individual structural variations to demographic and behavioral variates across a large cohort of healthy human volunteers. In particular, our findings shed some light on functional & structural integration, as we find a mode of structural variation that relates to and extends the positive-negative behavioral spectrum which was recently reported as being associated with variations in functional connectivity.\n\nSignificance statementThis work provides for the first-time strong evidence relating human brain structure variations to a wide range of demographic and behavioral measures. We show that several measures previously associated to variation in functional MRI connectivity are in fact already associated at the structural level, pointing towards structure-function integration.