NetLCP: An R package for prioritizing combinations of regulatory elements in the heterogeneous network with variant 'switches' detection

Abstract

Numerous independent networks of regulatory elements, including lncRNA, circRNA and pathway, have been developed to crucial roles in computational systems biology. Crosstalks among those networks as a bridge to build and decode heterogeneous networks from multidimensional biological knowledge, aids to highlight regulatory elements. And combinations of regulatory elements (CREs) in the local area of heterogeneous network have been a hot issue due to its crucial role in biological processes. We introduce NetLCP, an R package with command and shiny-based GUI modes, for prioritizing CREs with variant switches detection. Availability and implementationThe NetLCP package and documentations are freely available at https://github.com/mortyran/NetLCP. Supplementary informationSupplementary data are available online