Synaptic Encoding of Time in Working Memory

Abstract

AO_SCPLOWBSTRACTC_SCPLOWThe processing of temporally-extended sequences of stimuli critically relies on Working Memory (WM). Yet, how WM supports the encoding and retrieval of novel sequences is unknown. Existing theories rely on associative learning driven by repetitions and are, thus, unable to explain how people can reproduce novel sequences of stimuli immediately. Here, we propose that detailed temporal information about a novel sequence can be rapidly stored in WM by short-term synaptic plasticity over multiple time scales. To substantiate this proposal, we extend our previously-proposed synaptic theory of WM to include synaptic augmentation, besides more short-lived depression and facilitation, consistently with experimental observations. The long time scales associated with augmentation naturally lead to the emergence of a temporal gradient in the synaptic efficacies, which can be used to immediately replay, at normal speed or in a time-compressed way, novel sequences. The theory is consistent with behavioral and neurophysiological observations.