Graph Convolutional Learning of Multimodal Brain Connectome Data for Schizophrenia Classification

Abstract

The long term goal of this work is to develop powerful tools for brain network analysis in order to study structural and functional connectivity abnormalities in psychiatric disorders like schizophrenia. Graph convolutional neural networks (GCNN) are quite effective for learning complex discriminate features in graph-structured data. Here, we explore the GCNN to learn the discriminating features in multimodal human brain connectomes for the purpose of schizophrenia disorder classification. In particular, we train and validate a network using both structural connectivity graphs obtained from diffusion tensor imaging data and functional connectivity from functional magnetic resonance imaging data.We compare the GCNN method with a support vector machine based classifier and other popular classification benchmarks. We demonstrate that the proposed graph convolution method has the best performance compared to existing benchmarks with F1 scores of 0.75 for schizophrenia classification. This demonstrates the potential of this approach for multimodal diagnosis and prognosis in mental health disorders.