AndrologyGenetic & Genomic MedicinePeer-reviewed journal article
Androgen receptor polyQ alleles and COVID-19 severity in men: a replication study
Rosario López‐RodrígueziD, Javier Ruiz‐HornillosiD, Marta CortóniD, Berta AlmogueraiD, Pablo MíngueziD, María Elena Pérez-TomásiD, María Barreda‐SáncheziD, Esther ManceboiD, Lorena Ondo, Andrea Martínez‐RamasiD, Lidia Fernández‐CaballeroiD, Juan Carlos Taracido‐Fernández, Antonio HerreroiD, Ignacio MahílloiD, The STOP_Coronavirus Study Group, Estela Paz‐ArtaliD, Encarna Guillén‐NavarroiD, Carmen AyusoiD
Abstract
Ample evidence indicates a sex-related difference in severity of COVID-19, with less favorable outcomes observed in men. Genetic factors have been proposed as candidates to explain this difference. The polyQ polymorphism in the androgen receptor gene has been recently described as a genetic biomarker of COVID-19 severity. In this study, we analyzed this association in a large cohort of 1136 men classified into three groups according to their degree of COVID-19 severity, finding a similar distribution of polyQ alleles among severity groups. Therefore, our results do not support the role of this polymorphism as a biomarker of COVID-19 severity.
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- top 36%
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