Multi-method brain imaging reveals impaired representations as well as altered connectivity in adults with dyscalculia

Abstract

Two hypotheses have been proposed about the etiology of neurodevelopmental disorders: representation impairments versus disrupted access to representations. We implemented a multi-method brain imaging approach to directly compare the representation vs. access hypotheses in dyscalculia, a highly prevalent but understudied neurodevelopmental disorder in learning to calculate. We combined several magnetic resonance imaging methods and analyses, including multivariate analyses, functional and structural connectivity, and voxel-based morphometry analysis, in a sample of 24 adults with dyscalculia and 24 carefully matched controls. Results showed a clear deficit in the non-symbolic magnitude representations in parietal, temporal, and frontal regions in dyscalculia. We also observed hyper-connectivity in visual brain regions and increased grey matter volume in the default mode network in adults with dyscalculia. Hence, dyscalculia is related to a combination of diverse neural markers which are altogether distributed across a substantial portion of cerebral cortex, supporting a multifactorial model of this neurodevelopmental disorder.