Phasor diagrams clock oscillatory hemodynamic switching between overt speech production and micro resting states

Abstract

This study investigates the intricate interplay between the task-positive network and the default mode network (DMN) during transitions between overt language tasks and brief resting periods. While previous research suggests that these networks are not invariably anticorrelated, the precise timing of transitions has remained elusive. We employed rapid phase-encoded fMRI to decode brain dynamics with ultimate precision, capturing these transitions in real time. By utilizing phasor diagrams to represent the oscillatory activities, we examined the amplitudes and phases of hemodynamic fluctuations within the language network and DMN. Our findings align with existing empirical and theoretical perspectives on DMN functions and cognitive task performance, affirming the validity of our approach. We identified heterogeneous micro resting states interwoven with periods of overt speech production. Notably, various core regions of the DMN exhibited task-dependent amplitude and phase modulations, with activation strength and delay rising in line with increasing task complexity, ranging from comprehension to immediate and delayed speech production. This study sheds light on the dynamic engagement of the DMN during overt speech production, providing precise timing data of transitions between the DMN and language network. It demonstrates that rapid phase-encoded fMRI and phasor diagrams are powerful tools for measuring the switching between active tasks and micro resting states with subsecond accuracy, while also elucidating task load-dependent changes in the DMN. By accurately measuring the timing of these transitions, we gain insights into cognitive flexibility, attention, and the efficiency of information processing.