Reply to: Eigenmodes of the brain: revisiting connectomics and geometry

Abstract

In Pang, Aquino et al. (2023)1, we presented multiple lines of evidence to indicate that brain geometry plays a previously under-appreciated role in shaping dynamics. Mansour et al. raise concerns about one specific analysis, in which we showed that eigenmodes derived from the geometry of the human cortex can reconstruct diverse activity maps generated with functional magnetic resonance imaging (fMRI) better than eigenmodes derived from connectomes estimated with diffusion MRI (dMRI). Here, we address their concerns and show how our findings and conclusions remain valid.