Nature BiotechnologyBioinformaticsPeer-reviewed journal article
FAMSA2 enables accurate multiple sequence alignment at protein-universe scale
Adam GudyśiD, Andrzej ZielezińskiiD, Cédric NotredameiD, Sebastian DeorowicziD
Abstract
We introduce FAMSA2, an algorithm that produces high-accuracy multiple protein sequence alignments with unprecedented speed. Across structural, phylogenetic, and functional benchmarks, FAMSA2 matches or exceeds the accuracy of state-of-the-art tools while running up to 400 times faster and outperforming the fastest existing aligners. The ability of FAMSA2 to process 12 million sequences in 40 minutes on a 64 GB RAM workstation enables evolutionary and structural analyses at previously unattainable scales.
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- 12
- FWCI
- 23.01
- Field percentile
- top 1%
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