Individual brain activity patterns during task are predicted by distinct resting-state networks that may reflect local neurobiological features

Abstract

Understanding how individual cortical features shape functional brain organization offers a promising framework for examining the principles of cognitive specialization in the human brain. This study explores the relationship between various cortical characteristics--i.e resting-state functional connectivity, structural connectivity, microstructure, morphology, and geometry--and the layout of task-specific functional activations. We employ linear models to predict the functional layout of the cortex at the individual level from each of these feature modalities. Our findings demonstrate that resting-state component loadings predict individual task activations, consistently across hemispheres and independent datasets. Whereas the first few components provide a common space for functional activations across tasks, predictive higher-order component loadings demonstrated task-specificity. Cortical microstructure/morphology was notably predictive of activation strength in the occipital cortex, highlighting its relevance for cortical functional specialization. By relating resting state components to a set of reference maps of cortical organization, we identify associations that suggest possible neurobiological underpinnings of specific cognitive functions. The remaining feature modalities were only predictive of group-level functional activations. These results advance our understanding of how distinct cortical features may contribute to functional specialization, guiding future inquiry into the organization of cognitive functions on the cortex.