bioRxivNeurosciencePreprint
Optimizing femtosecond laser fabricating strategy of Nitinol hypotube for vascular interventional surgery
Yunfeng Song, Zhiwei Yang, Tongjun XuiD, Hao XieiD, Depeng WangiD, Lan CheniD, Xusan YangiD
Abstract
Guidewires and catheters are essential in minimally invasive procedures, particularly in accessing targets within the vascular system for neuron surgery. Femtosecond lasers can precisely cut nickel-titanium micro tubes, known as Nitinol hypotubes, serving as the heads of micro guidewires while protecting their core tips. The quality and geometry of these hypotubes depend on the focus of the laser cutting system. We evaluated the cutting efficiency and quality of Nitinol hypotubes using objective lenses with three numerical apertures (NA). Quantitative analysis indicated that higher NA objectives yield better surface quality, resulting in lower debris. Additionally, cutting with high NA objectives produced significantly lower arithmetic mean surface roughness and enhanced mechanical properties. Using a two-temperature model, we simulated the interaction between femtosecond lasers and Nitinol, showing that higher NA objectives increase electron temperatures, thus improving material removal efficiency. This study also tested the optimized Nitinol hypotube prformance in simulations of invasive neuron surgery.
- Citations
- 0
Reproducibility ledger
Nobody has reported trying to reproduce this paper yet. Did you replicate an experiment or run the code? Your report saves the next lab a week.
Sign in to file a reproducibility report.
Related papers
- Visibly Transparent, Near-Infrared Absorbing Nanofluids Enable High-Efficiency and Safe Laser Lithotripsy
Qingsong Fan, Junqin Chen, … Po‐Chun Hsu·bioRxiv·Jun 3, 2026
- Ytterbium-doped fibre femtosecond laser offers robust design with deep and precise microsurgery
MB Harreguy, Vanessa Marfil, … Gal Haspel·bioRxiv·Nov 4, 2019
- Robotic Laser Tissue Soldering for Damage-free Soft Tissue Fusion Guided by Fluorescent Nanothermometry
O. Cipolato, T. Leuthold, … I. K. Herrmann·bioRxiv·Feb 29, 2024
- Guided Axon Outgrowth of Neurons by Real-Time Femtosecond Laser Penetration on a 4 μm Thick Thin-Glass Sheet
D. Anggraini, X. Liu, … Y. Yalikun·bioRxiv·Aug 17, 2021
- Nanothermometry-enabled intelligent laser tissue soldering
O. Cipolato, L. Dosnon, … I. K. Herrmann·bioRxiv·Mar 3, 2023
- Nanofluid-Enhanced Laser Lithotripsy Using Conducting Polymer Nanoparticles
Qingsong Fan, Junqin Chen, … Po‐Chun Hsu·Advanced SciencePeer-reviewed·Oct 5, 2025