An exploratory study of EEG connectivity during the first year of life in preterm and full-term infants

Abstract

AimTo evaluate electroencephalography (EEG) connectivity during the first year of age in healthy full-term infants and preterm infants with prenatal and perinatal risk factors for perinatal brain damage. MethodsThree groups of infants were studied: healthy full-term infants (n = 71), moderate/late-preterm infants (n = 54), and very preterm infants (n = 56). All preterm infants had perinatal and/or perinatal risk factors for brain damage. EEG was obtained during phase II of natural nonrapid eye movement (NREM) sleep. EEG analysis was performed in 24 2.56-s artifact-free segments. For the calculation of EEG sources, spectral structured sparse Bayesian learning was used. Connectivity was computed by the phase-lag index. ResultsIn healthy full-term infants, EEG interhemispheric connectivity in the different frequency bands followed similar trends with age to those reported in each frequency band: delta connectivity decreased, theta increased at the end of the year, the alpha band showed different trends based on the region studied, and beta interhemispheric connectivity decreased with age. EEG connectivity in preterm infants showed differences from the results of the term group. DiscussionImportant structural findings may explain the differences observed in EEG connectivity between the term and preterm groups. ConclusionThe study of EEG connectivity during the first year of age provides essential information on normal and abnormal brain development.