Alzheimer s & Dementia Diagnosis Assessment & Disease MonitoringNeurosciencePeer-reviewed journal article
Cochlear dysfunction as an early biomarker for cognitive decline in normal hearing and mild hearing loss
Vicente MedeliD, Paul Hinckley DelanoiD, Chama BelkhiriaiD, Alexis Leiva C.iD, Cristina De Gatica, Victor Vidal, Carlos F. NavarroiD, Simón San MartíniD, Melissa MartíneziD, Christine Gierke, Ximena García, Mauricio CerdaiD, Rodrigo Clemente VergaraiD, Carolina DelgadoiD, Gonzalo A. FariasiD
- Citations
- 14
- FWCI
- 3.40
- Field percentile
- top 7%
Abstract
Age-related hearing loss (presbycusis) at moderate levels (>40 dB HL) has been recognized as an important risk factor for cognitive decline. However, whether individuals with mild hearing loss (audiogram thresholds between 25 and 40 dB HL) or even those with normal audiograms (64 years old. In addition, cognitive and functional performance was evaluated with the Clinical Dementia Rating Sum of Boxes (CDR SoB), assessed through structured interviews conducted by neurologists, who were blind to the DPOAE results. We found that cochlear dysfunction, measured by DPOAE -and not by conventional audiometry-, was associated with CDR SoB classification and brain atrophy in the group with mild hearing loss (25 to 40 dB), and normal hearing (<25 dB). Our findings suggest that DPOAE may be a non-invasive tool for detecting neurodegeneration and cognitive decline in the elderly, potentially allowing for early intervention.
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