Fully Convolutional Networks for pathophysiological Intracranial Pressure waveform classification

Abstract

It is generally assumed that the analysis of intracranial pressure (ICP) waveforms could be used for the detection of multiple cerebral pathophysiologies. A main obstacle for the analysis of ICP waveforms is given by the large variation of their generating signal, the arterial blood pressure (ABP). Using extended principal component analysis (PCA) we show that it is possible to distinguish between ICP waveforms generated by pathological ABP waveforms, e.g. in the case of a heart failure, without loosing information about the state of the cerebral compliance. We also create a dataset for ICP pulse classification that can be used to train models to distinguish between an intact and diminished cerebral compliance, as a function of the ICP-generating ABP pulse. As a baseline for classification we build a fully convolutional network (FCN) that reaches high performance with relatively few data.