Association of bidirectional network cores in the brain with perceptual awareness and cognition

Abstract

The brain comprises a complex network of interacting regions. To understand the roles and mechanisms of this intricate network, it is crucial to elucidate its structural features related to cognitive functions. Recent empirical evidence suggests that both feedforward and feedback signals are necessary for conscious perception, emphasizing the importance of subnetworks with bidirectional interactions. However, the link between such subnetworks and conscious perception remains unclear due to the complexity of brain networks. In this study, we propose a framework for extracting subnetworks with strong bidirectional interactions--termed the "cores" of a network--from brain activity. We applied this framework to resting-state and task-based human fMRI data from participants of both sexes to identify regions forming strongly bidirectional cores. We then explored the association of these cores with conscious perception and cognitive functions. We found that the extracted central cores predominantly included cerebral cortical regions rather than subcortical regions. Additionally, regarding their relation to conscious perception, we demonstrated that the cores tend to include regions previously reported to be affected by electrical stimulation that altered conscious perception, although the results are not statistically robust due to the small sample size. Furthermore, in relation to cognitive functions, based on a meta-analysis and comparison of the core structure with a cortical functional connectivity gradient, we found that the central cores were related to unimodal sensorimotor functions. The proposed framework provides novel insights into the roles of network cores with strong bidirectional interactions in conscious perception and unimodal sensorimotor functions. Significance StatementTo understand the brains network, we need to decipher its structural features linked to cognitive functions. Recent studies suggest the importance of subnetworks with bidirectional interactions for conscious perception, but their exact relationship remains unclear due to the brains complexity. Here we propose a framework for extracting subnetworks with strong bidirectional interactions, or network "cores." We applied it to fMRI data and explored the association of the cores with conscious perception and cognitive functions. The central cores predominantly included cortical regions rather than subcortical ones, and tended to comprise previously reported regions wherein electrical stimulation altered perception, suggesting the potential importance of bidirectional cores for conscious perception. Additionally, further analysis revealed the relationship of the cores to unimodal sensorimotor functions.