A familiar face and person processing area in the human temporal pole

Abstract

How does the brain process the faces of familiar people? Neuropsychological studies have argued for an area of the temporal pole (TP) linking faces with person identities, but magnetic susceptibility artifacts in this region have hampered its study with fMRI. Using data acquisition and analysis methods optimized to overcome this artifact, we identify a familiar face response in TP, reliably observed in individual brains. This area responds strongly to visual images of familiar faces over images of unfamiliar faces, objects, and scenes. However, TP did not just respond to images of faces, but also to a variety of high-level cognitive tasks that involve thinking about people, including semantic, episodic, and theory of mind tasks. The response profile of TP contrasted from a nearby region of perirhinal cortex that responded specifically to faces, but not to social cognition tasks. TP was functionally connected with a distributed network in association cortex associated with social cognition, while PR was functionally connected with face-preferring areas of ventral visual cortex. This work identifies a missing link in the human familiar face processing system that specifically processes familiar faces, and is well placed to integrate visual information about faces with higher-order conceptual information about other people. The results suggest that separate streams for person and face processing reach anterior temporal areas positioned at the top of the cortical hierarchy.