Genetic parameters for resistance to gastrointestinal nematodes in sheep: a meta-analysis

Abstract

Gastrointestinal nematodes (GIN) are damaging parasites of global sheep populations. The key weapons in fighting GIN have been anthelmintic drugs, but the emergence of drug-resistant parasites has meant that alternative control methods are needed. One of these alternatives is to breed for enhanced host resistance to GIN, and decades of research have estimated the genetic contribution to different measures of resistance to GIN and their genetic correlations with other desirable performance traits. It is clear that parasite resistance is a heritable trait that can be selected for. Despite this consensus, estimates of both heritability of resistance and genetic correlations with other traits vary widely between studies, and the reasons for this variation have not been examined. This study provides a comprehensive and quantitative meta-analysis of genetic parameters for resistance to GIN in sheep, including measures of worm burden (faecal egg counts, FEC), anti-parasite immunity (GIN-specific antibodies), and parasite-induced pathology (FAMACHA(C) scores). Analysis of 591 heritability estimates from 121 studies revealed a global heritability estimate for resistance to GIN of 0.25 (95%CI = 0.22 - 0.27) that was stable across breeds, ages, geographical location and analytical methods. Meanwhile, analysis of 559 genetic correlations from 54 studies revealed that resistance to GIN overall has a positive genetic correlation of +0.10 (95%CI = 0.02 - 0.19) with performance traits, and that this was consistent across breeds, ages, sexes and analytical methods. Importantly, the direction of the genetic correlation varied with the resistance trait measured: while FEC and FAMACHA(C) scores were favourably correlated with performance traits, adaptive immune markers were unfavourably correlated, suggesting that selection for enhanced immune responses to GIN could reduce animal performance. Overall, the results suggest that breeding for resistance to GIN should continue to form part of integrated management programs to reduce the impact of parasites on health and performance, but that selection for enhanced immune responses should be avoided.