bioRxivGenetics
Cell specific eQTL analysis without sorting cells
Harm-Jan WestraiD, Danny Arends, Tõnu EskoiD, Marjolein J. PetersiD, Claudia SchurmanniD, Katharina SchrammiD, Johannes KettuneniD, Hanieh YaghootkariD, Benjamin Fairfax, Anand Kumar AndiappaniD, Yang LiiD, Jingyuan FuiD, Juha Karjalainen, Mathieu Platteel, Marijn Visschedijk, Rinse Weersma, Silva KaselaiD, Lili Milani, Liina Tserel, Pärt Peterson, Eva Reinmaa, Albert HofmaniD, André G. Uitterlinden, Fernando RivadeneiraiD, Georg HomuthiD, , Dena
Abstract
Expression quantitative trait locus (eQTL) mapping on tissue, organ or whole organism data can detect associations that are generic across cell types. We describe a new method to focus upon specific cell types without first needing to sort cells. We applied the method to whole blood data from 5,683 samples and demonstrate that SNPs associated with Crohn's disease preferentially affect gene expression within neutrophils.
- organism: human
- assay: bulk RNA-seq
- research focus: eQTL / molecular QTL mapping
- approach: statistical model
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