Structure-based learning to model complex protein-DNA interactions and transcription-factor co-operativity in cis-regulatory elements
Oriol Fornés, A Meseguer, Joaquim Aguirre‐Plans, Patrick Gohl, Patricia Mirela Bota, Rubén Molina-Fernández, Jaume Bonet, AC Hernandez, Ferran Pegenaute, Oriol Gallego, Narcís Fernández‐Fuentes, Baldomero Oliva
The paper introduces a structure-based learning approach to predict TF binding preferences and model TF regulatory complexes, demonstrating its effectiveness over existing methods in cases of remote homology.
bioRxiv · Apr 17, 2022 · PreprintBioinformatics