Chemotherapy induced immunogenic cell death alters response to exogenous activation of STING pathway and PD-L1 immune checkpoint blockade in a syngeneic murine model of ovarian cancer.
S. Nersesian, N. Shakfa, N. Peterson, T. Vidotto, A. AfriyieAsante, E. Lightbody, M. Koti
This study shows that chemotherapy type affects the response to STING pathway activation and PD-L1 blockade in a murine model of ovarian cancer, with carboplatin + STING + PD-L1 providing the best survival.
bioRxiv · Oct 30, 2019 · PreprintCancer Biology