Rapid expansion of SARS-CoV-2 variants of concern is a result of adaptive epistasis
M. R. Garvin, E. T. Prates, J. Romero, A. Cliff, J. G. F. M. Gazolla, M. Pickholz, M. Pavicic, D. Jacobson
The paper analyzes SARS-CoV-2 genomes to show that adaptive epistasis, not just spike mutations, drives the emergence of variants of concern.
bioRxiv · Aug 3, 2021 · PreprintEvolutionary Biology