Hydroquinone, a cigarette smoke compound, affects cartilage homeostasis through activation of the aryl hydrocarbon receptor pathway.
C. S. Heluany, A. de Palma, N. J. Day, S. H. P. Farsky, G. Nalesso
This study shows hydroquinone, a cigarette smoke compound, harms cartilage by activating the AhR pathway, reducing SOX-9 and Col2a1 while increasing MMP-3 and ADAMTS5.
bioRxiv · Apr 25, 2022 · PreprintPharmacology & Toxicology