Local topology, bifurcations and mutation hot-spots in proteins with SARS-CoV-2 spike protein as an example
The paper introduces topological methods to identify mutation hot-spot sites in proteins, using the SARS-CoV-2 spike protein as an example, and finds that D614G and N501Y are notable hot-spots.
bioRxiv · Nov 11, 2020 · PreprintBiophysics