Decoding Angiotensin II Type 1 Receptor Allosteric Communication to Gq and β-arrestin
A. K. Nivedha, Y. Cao, S. Lee, S. Bhattacharya, S. Laporte, N. Vaidehi
This study identifies residue networks mediating allosteric communication from the Ang II binding site to Gq and β-arrestin2 coupling sites in AT1R, revealing shared and distinct residues that could guide biased ligand design.
bioRxiv · May 17, 2021 · PreprintBiophysics