Assessing the Generalization Capabilities of TCR Binding Predictors via Peptide Distance Analysis
L. V. Castorina, F. Grazioli, P. Machart, A. Moesch, F. Errica
This paper evaluates how well TCR binding predictors generalize to unseen peptides by analyzing the distance between training and testing peptide distributions using sequence and 3D structure metrics.
bioRxiv · Jul 29, 2023Immunology