Class A GPCRs use the membrane potential to increase their sensitivity and selectivity
D. Shalaeva, D. Cherepanov, M. Galperin, G. Vriend, A. Mulkidjanian
This study shows that class A GPCRs use the membrane potential to enhance their sensitivity and selectivity by coupling sodium ion translocation to receptor activation.
bioRxiv · Mar 23, 2019 · PreprintBiophysics