T-cell receptor specific protein language model for prediction and interpretation of epitope binding (ProtLM.TCR)
Ahmed Essaghir, Nanda Kumar Sathiyamoorthy, Paul Smyth, A. Postelnicu, Stefan Ghiviriga, Alexandru Ghita, Anjana Singh, Shruthi Kapil, Sanjay Kumar Phogat, Gurpreet Singh
The paper introduces ProtLM.TCR, a TCR-specific language model for predicting TCR-epitope binding and shows it outperforms BLOSUM scores and hand-crafted embeddings.
bioRxiv · Nov 28, 2022 · PreprintBioinformatics