Diverse Protein Architectures and α-N-Methylation Patterns Define Split Borosin RiPP Biosynthetic Gene Clusters
A. S. Imani, A. R. Lee, N. Vishwanathan, F. de Waal, M. F. Freeman
The paper identifies over 1,600 split borosin biosynthetic gene clusters in bacteria using hidden Markov models and sequence similarity networks, revealing six structural types with validated differences in precursor and methylation patterns.
bioRxiv · Dec 24, 2021Biochemistry