Amyloid-β peptide dimers undergo a random coil to β-sheet transition in the aqueous phase but not at the neuronal membrane
H. Fatafta, M. Khaled, A. Sayyed-Ahmad, B. Strodel
This study uses molecular dynamics simulations to show that Aβ42 dimers form β-sheets in solution but not at neuronal membranes, with GM1 gangliosides inhibiting ordered oligomer formation.
bioRxiv · Dec 31, 2020Biophysics