A. Sharir-Ivry

Quantifying Evolutionary Importance of Protein Sites: A Tale of Two Measures

The paper quantifies evolutionary importance of protein sites using two measures and finds a strong linear relationship between them, with catalytic sites being an exception.

Non-catalytic binding sites induce weaker long-range evolutionary rate gradients than catalytic sites in enzymes

The paper shows that catalytic sites in enzymes induce stronger evolutionary rate gradients than non-catalytic binding sites, suggesting catalytic optimization drives these gradients.