The Prion Protein Octarepeat Domain Forms Transient β-sheet Structures Upon Residue-Specific Cu(II) and Zn(II) Binding
M. Gielnik, A. Szymanska, X. Dong, J. Jarvet, Z. M. Svedruzic, A. Graslund, M. Kozak, S. K. T. S. Warmlander
This study investigates how Cu(II) and Zn(II) binding affects the structure of the prion protein's octarepeat domain, suggesting a potential role in amyloid formation in TSEs.
bioRxiv · Dec 12, 2021 · PreprintBiophysics