Meta-GWAS Accuracy and Power (MetaGAP) calculator shows that hiding heritability is partially due to imperfect genetic correlations across studies
R. de Vlaming, A. Okbay, C.A. Rietveld, M. Johannesson, P.K.E. Magnusson, A.G. Uitterlinden, F.J.A. van Rooij, A. Hofman, P.J.F. Groenen, A.R. Thurik, P.D. Koellinger
The paper introduces MetaGAP, a calculator that quantifies how cross-study genetic heterogeneity reduces GWAS power and polygenic score accuracy, showing it contributes to missing heritability.
PLOS Genetics · Jan 17, 2017Peer-reviewedGenetics