Oncogenic chromodomain mutations allosterically impair TIP60 acetyltransfearse function preventing activation of DNA repair genes under genotoxic stress
Himanshu Gupta, Aarushi Bansal, Ashish K. Gupta
This study identifies how chromodomain mutations in TIP60 impair its acetyltransferase function, leading to reduced DNA repair gene activation and genomic instability.
bioRxiv · Feb 24, 2026 · PreprintMolecular Biology