Mind the Gap: An Embedding Guide to Safely Travel in Sequence Space
Adam Wu, Quentin Trolliet, Abhinav Rajendran, Jakub Lála, Stefano Angioletti‐Uberti
The paper introduces a hybrid method using a protein language model and Monte Carlo sampling to generate enzyme mutants that preserve structural features while varying overall sequence, providing sequences for experimental testing.
PLoS Computational Biology · Jul 9, 2026Peer-reviewedSynthetic Biology