Extended pre-training of histopathology foundation models uncovers co-existing breast cancer archetypes characterized by RNA splicing or TGF-β dysregulation
Lisa Mathilde Fournier, Garance Haefliger, Ablin EP Vernhes, Vincent Jung, Igor Letovanec, Pascal Frossard B, Cédric Vincent-Cuaz, Raphaëlle Luisier
This paper extends pre-training of histopathology foundation models to specialize them for tumor tissue, revealing two coexisting breast cancer archetypes defined by RNA splicing and TGF-β dysregulation.
bioRxiv · Mar 27, 2025 · PreprintCancer Biology