High-fat diet feeding reduces the expression of Rab3a, Rab3gap1, and Rab3Gap2 genes that are pivotal to neuronal exocytosis.
Luana Assis Ferreira, Fernando Victor Martins Rubatino, Mariana Lacerda de Freitas, Leonardo Rossi de Oliveira, Célio José de Castro, Fernanda Sarquis Jehee, Adriana Bosco, Karla Fernandes
This study shows that high-fat diet feeding reduces Rab3a, Rab3gap1, and Rab3gap2 gene expression in the hypothalamus, potentially disrupting neuronal exocytosis and receptor recycling.
bioRxiv · Sep 10, 2021 · PreprintNeuroscience