The genetic dissection of fetal haemoglobin persistence in sickle cell disease in Nigeria
Oyesola Oyewole Ojewunmi, Titilope Adenike Adeyemo, Ajoke Idayat Oyetunji, Bassey A. Inyang, Afolashade Akinrindoye, Baraka Stewart Mkumbe, Kate Gardner, Helen Rooks, John N. Brewin, Hamel Patel, Sang Hyuck Lee, Raymond Chung, Sara R. Rashkin, Guolian Kang, Reuben Ikechukwu Chianumba, , Stephan Menzel
This paper conducts a genome-wide association study in Nigerian sickle cell disease patients to identify genetic variants associated with fetal hemoglobin levels, finding significant associations at BCL11A and HBS1L-MYB and novel signals in the Nigerian cohort.
Human Molecular Genetics · Jan 18, 2024Peer-reviewedGenetic & Genomic Medicine