Hierarchical Deep Learning Framework Integrating Structural Interaction Potentials and Evolutionary Information for Protein-Protein Interaction Affinity Prediction
Ahmed F. Ibrahim, Mohamed Hassan, Youssef Ali
This paper introduces StructFuncNet, a deep learning framework for predicting protein-protein interaction affinity using structural and evolutionary data, achieving state-of-the-art performance across multiple benchmarks.
bioRxiv · Jan 12, 2026 · PreprintBioinformatics