Penetrance of polygenic obesity susceptibility loci across the body mass index distribution: an update on scaling effects.
Arkan Abadi, Akram Alyass, Sébastien Robiou-du-Pont, Benjamin M. Bolker, Pardeep Singh, Viswanathan Mohan, Rafael Díaz, James C. Engert, Hertzel C. Gerstein, Sonia Savitri Anand, David Meyre
The paper examines how the effects of BMI-associated SNPs vary across BMI percentiles and finds that 9 out of 37 SNPs show increasing effects with higher BMI.
bioRxiv · Nov 29, 2017 · PreprintGenetics